RISK FACTORS OF DCM 1 and DCM 2
The easiest way to picture this is:
Researchers have discovered mutations on 4 genes which are associated with DCM disease in Dobermans. A dog can have anywhere from zero mutations to one, two, three or four. The more mutations, the higher the risk of the dog developing DCM. The best possible result is a "Clear" result for the DCM 1 test which tests for 2 of the mutations, and a "Clear" on the DCM 2 test, which tests for the other 2 mutations. Below is some additional information on risk factors of dogs who have been tested.
Negative Result for both DCM1 and DCM2:
The absence of both mutations in a Doberman indicates that the risk of developing DCM is low. It is still possible for a dog to develop heart disease. However, a negative result for both DCM1 and DCM2 indicates that a dog does not have either mutation known to cause DCM.
Positive result for DCM1 only:
About 40% of dogs with this mutation will develop DCM. Dogs that are positive for only DCM1 will not necessarily develop significant heart disease.
Breeding recommendations:
Dogs are positive for DCM1 should NEVER be bred to a dog that is positive for NCSU DCM 2 since this will lead to dogs that are highest risk of developing DCM. Dogs that are positive homozygous for DCM1 should ideally not be bred.
Positive Result for NCSU DCM2 only:
About 50% of dogs with this mutation will develop DCM. Dogs that are positive for only DCM2 will not necessarily develop significant heart disease.
Breeding recommendations:
Dogs are positive for DCM2 should NEVER be bred to a dog that is positive for NCSU DCM1 (PDK4) since this will lead to dogs that are highest risk of developing DCM. Dogs that are positive homozygous for DCM2 should ideally not be bred.
Positive result for both DCM1 and NCSU DCM2:
Dogs that positive for BOTH DCM1 & DCM2 are at a very HIGH risk of developing DCM and should be carefully monitored by your veterinarian for signs of disease. Annual evaluation by a cardiologist with an echocardiogram and Holter monitor after 3 years of age is recommended.
Breeding recommendations:
Dogs that are positive for both DCM1 & DCM2 are at the HIGHEST risk of developing DCM and should ideally not be bred since they can pass both traits on. They should never be bred to a dog that is positive for either test.
DANBAR RANCH DOBERMANS ARE ALL DCM1 and DCM2 CLEAR.